Production of prostaglandins and leukotrienes by pathogenic fungi.
نویسندگان
چکیده
These studies demonstrate that pathogenic fungi (dermatophytic, subcutaneous, and systemic) have the ability to produce eicosanoids both from simple metabolites and from arachidonic acid. Host-derived eicosanoids have been previously demonstrated to enhance fungal colonization and atopic disease development. Thus, fungus-derived eicosanoids represent a potential class of novel virulence factors.
منابع مشابه
Production of eicosanoids and other oxylipins by pathogenic eukaryotic microbes.
Oxylipins are oxygenated metabolites of fatty acids. Eicosanoids are a subset of oxylipins and include the prostaglandins and leukotrienes, which are potent regulators of host immune responses. Host cells are one source of eicosanoids and oxylipins during infection; however, another potential source of eicosanoids is the pathogen itself. A broad range of pathogenic fungi, protozoa, and helminth...
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ورودعنوان ژورنال:
- Infection and immunity
دوره 70 1 شماره
صفحات -
تاریخ انتشار 2002